Immunology and aging.

Abstract

Aging is accompanied by numerous functional and phenotypic changes in T cells, B cells and monocytes/macrophages; moreover, increases in autoimmunity, infections and occurrence of cancer have been reported in aged people. Healthy elderly persons, defined according to the criteria of the SENIEUR protocol, show various alterations in immunocompetent cells. Recent data have shown that the distribution of the subsets of peripheral blood, T-cell subtypes, is influenced by age. With increasing age, CD45RA(+) naive cells are replaced by CD45RA(-) memory CD4(+) T cells. In the CD8(+) T-cell subset, we found an increased proportion of cells co-expressing CD57. In monocytes also, some alterations of the immunophenotype, for example the expression of the adhesion molecule CD54, were observed. A relative deficit of transendothelial migration with aging was found in T cells, whereas this function was not impaired in monocytes. The immunophenotype and the function of dendritic cells do no t appear to be affected by aging. Due to their capacity to present antigens to T cells and to induce T-cell proliferation, dendritic cells may provide a useful tool for immunotherapy. In conclusion, investigations of immune functions in aging people reveal that there is an alteration of the immunophenotype of T cells and monocytes. Several functions of T-cell accompanying mechanisms, for example cytokine production and cell migration, are also affected by aging. In contrast, dendritic cells do not seem to be influenced by the aging process.