Controlling stem cell proliferation: CKIs at work.

Sophia W M Bruggeman; Maarten van Lohuizen

doi:10.4161/cc.5.12.2806

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PubMed · 16760652

Controlling stem cell proliferation: CKIs at work.

Sophia W M Bruggeman·Maarten van Lohuizen

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Abstract

The cyclin-dependent kinase inhibitors or CKIs are well recognized as intrinsic regulators of the cell cycle. Here, we discuss recent data implicating their activity in restraining adult stem cell self-renewal, and the role that proteins regulating CKI expression play in this process.

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Animals Cell Cycle Cell Proliferation Cellular Senescence Cyclin-Dependent Kinase Inhibitor Proteins Humans Protein Binding Stem Cells Journal Article Research Support, Non-U.S. Gov't

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Sophia W M Bruggeman, Maarten van Lohuizen. 2006-06-15. Controlling stem cell proliferation: CKIs at work.. https://doi.org/10.4161/cc.5.12.2806

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