Anaplerotic molecules: current and future.

Henri Brunengraber; Charles R Roe

doi:10.1007/s10545-006-0320-1

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PubMed · 16763895

Anaplerotic molecules: current and future.

Henri Brunengraber·Charles R Roe

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Abstract

This review presents the concepts of anaplerosis and cataplerosis in relation to the regulation of citric acid cycle operation. Anaplerosis is the re-filling of the catalytic intermediates of the cycle that carry acetyl-CoA as it is oxidized. The main anaplerotic substrates are pyruvate, glutamine/glutamate and precursors of propionyl-CoA (odd-chain fatty acids, specific amino acids, C(5)-ketone bodies). Cataplerosis balances anaplerosis by removing excess intermediates from the citric acid cycle. The properties of the main anaplerotic substrates are reviewed from the point of view of potential clinical applications to the treatment of some inherited and acquired conditions.

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Acyl Coenzyme A Animals Citric Acid Cycle Glutamic Acid Glutamine Heptanoates Humans Ketone Bodies Metabolism, Inborn Errors Propionates Pyruvic Acid Reperfusion Injury Triglycerides Valerates Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Henri Brunengraber, Charles R Roe. Anaplerotic molecules: current and future.. https://doi.org/10.1007/s10545-006-0320-1

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