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Oxygen sensors in hypoxic pulmonary vasoconstriction.

Norbert Weissmann·Natascha Sommer·Ralph Theo Schermuly·Hossein Ardeschir Ghofrani·Werner Seeger·Friedrich Grimminger
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Abstract

Hypoxic pulmonary vasoconstriction (HPV) is an essential mechanism adapting lung perfusion to regional ventilation. Perturbations to HPV, such as those occurring in pneumonia, acute respiratory distress syndrome and liver failure, can result in arterial hypoxemia. Under conditions of general hypoxia, HPV increases pulmonary vascular resistance and thus causes acute pulmonary hypertension. Despite intensive research, the underlying mechanisms of HPV have not been fully elucidated. Deciphering signalling pathways that result in HPV could suggest novel approaches to address a failure of HPV, as well as for the treatment of pulmonary hypertension associated with HPV. Within this context, this review focuses on current concepts in the oxygen sensing mechanisms that underlie HPV.

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Adenosine TriphosphateAnimalsCalciumCytochrome P-450 Enzyme SystemHeme Oxygenase (Decyclizing)HumansHypertension, PulmonaryHypoxiaLungMitochondriaOxygenReactive Oxygen SpeciesVasoconstrictionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Norbert Weissmann, Natascha Sommer, Ralph Theo Schermuly, Hossein Ardeschir Ghofrani, Werner Seeger, Friedrich Grimminger. 2006-09-01. Oxygen sensors in hypoxic pulmonary vasoconstriction.. https://doi.org/10.1016/j.cardiores.2006.04.009

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