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PubMed · 16768113

[Adipokine interrelationship with the liver].

Yoshiyuki Takei·Nobuhiro Sato
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Abstract

Recent progress in adipocyte biology delineates that adipocytes not only store excess energy, but also respond to metabolic signals by secreting proteins that exert local, central, and peripheral effects. Among these adipokines are free fatty acids, plasminogen activator inhibitor-1, angiotensinogen, TNFa, leptin and adiponectin. Dysregulation of production of these adipokines and/or imbalance of their actions lead to a wide array of liver and systemic pathophysiology related to NASH such as 1) development of systemic and hepatic insulin resistance, 2) progression from benign fatty liver to steatohepatitis and 3) activation of hepatic fibrogenesis. This review deals with the emerging concept of the adipokine interrelationship with the liver.

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AdipocytesAdiponectinAngiotensinogenAnimalsFatty LiverFibrosisHumansInsulin ResistanceLeptinLiverPlasminogen Activator Inhibitor 1Tumor Necrosis Factor-alphaEnglish AbstractJournal ArticleReview

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Yoshiyuki Takei, Nobuhiro Sato. 2006. [Adipokine interrelationship with the liver].. https://pubmed.ncbi.nlm.nih.gov/16768113/

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