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MALDI-MS data analysis for disease biomarker discovery.

Weichuan Yu·Baolin Wu·Junfeng Liu·Xiaoye Li·Kathy Stone·Kenneth R Williams·Hongyu Zhao
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Abstract

In this chapter, we address the issue of matrix-assisted laser desorption/ionization mass spectrometry (MS) data analysis for disease biomarker discovery. We first give a general framework of MS data analysis, then focus on several key steps. After that, we show some application examples using an ovarian sera cancer dataset. Finally, we discuss the limitations of current approaches and possible future research directions.

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AnimalsBiomarkersComputational BiologyHumansMass SpectrometryModels, StatisticalPeptide MappingProteomicsSequence Analysis, ProteinSpectrometry, Mass, Matrix-Assisted Laser Desorption-IonizationJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, U.S. Gov't, Non-P.H.S.

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Weichuan Yu, Baolin Wu, Junfeng Liu, Xiaoye Li, Kathy Stone, Kenneth R Williams, Hongyu Zhao. 2006. MALDI-MS data analysis for disease biomarker discovery.. https://doi.org/10.1385/1-59745-026-x%3A199

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