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Thymic stromal lymphopoietin in normal and pathogenic T cell development and function.

Steven F Ziegler·Yong-Jun Liu
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Abstract

Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell-mediated allergic inflammation.

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AnimalsCell MovementClonal DeletionCytokinesDendritic CellsDermatitis, AtopicDimerizationEpithelial CellsHomeostasisHumansHypersensitivity, ImmediateImmunoglobulinsInflammationMembrane GlycoproteinsMiceOX40 LigandReceptors, CytokineReceptors, Interleukin-7Signal TransductionStromal CellsT-Lymphocyte SubsetsThymus GlandTumor Necrosis FactorsThymic Stromal LymphopoietinJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReview

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Steven F Ziegler, Yong-Jun Liu. 2006. Thymic stromal lymphopoietin in normal and pathogenic T cell development and function.. https://doi.org/10.1038/ni1360

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