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Analysing the output from primary screening.

Dawn Nowlin·Patrick Bingham·Andrew Berridge·Philip Gribbon·Philip Laflin·Andreas Sewing
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Abstract

From a perspective of process knowledge and enhancement, the analysis of the results of biological screening should not be limited to the outcome of specific projects, but additionally encompass a process centric view. Summarising outcomes across multiple projects is a powerful tool to gain a greater understanding of biological screening that will also enable optimisation of the strategy for specific projects or target classes. We have analysed a set of 73,651 compounds with reproducible (confirmed) results from 63 high-throughput screening (HTS) campaigns to reveal the underlying trends in the population of active compounds. We have focused on the overall physico-chemical profile of compound populations derived from biological screening since the in vivo activity of drug molecules is the result of physico-chemical and structural properties of the compound.

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Dawn Nowlin, Patrick Bingham, Andrew Berridge, Philip Gribbon, Philip Laflin, Andreas Sewing. 2006. Analysing the output from primary screening.. https://doi.org/10.2174/138620706777452401

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