Coagulation and sepsis.

F R Machado; E Silva

doi:10.2174/187153006777442369

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PubMed · 16787292

Coagulation and sepsis.

F R Machado·E Silva

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Abstract

Sepsis is a complex disease and coagulation derangements are part of this context. The inflammatory storm is ultimately responsible for coagulation derangements. It is characterized by exacerbated coagulation, impaired anticoagulation and decreased fibrin removal. These derangements are implicated in the generation of microcirculation thrombosis, with deposition of microclots and obstruction of circulation, impairing blood flow and contributing to tissue hypoperfusion and consequently, organ dysfunction. This review will address the main issues regarding coagulation disorders in the context of sepsis.

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Antithrombins Blood Coagulation Blood Coagulation Factors Fibrinolysis Humans Lipoproteins Receptors, Cell Surface Sepsis Journal Article Review

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F R Machado, E Silva. 2006. Coagulation and sepsis.. https://doi.org/10.2174/187153006777442369

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