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Association between infectious diseases and type 1 diabetes: a case-crossover study.

Ze Yang·Fan Zhou·Janice Dorman·Huijuan Wang·Xiaoquan Zu·Sati Mazumdar·Ronald E LaPorte
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Abstract

BACKGROUND: To investigate the role of infectious diseases in the development of type 1 diabetes, this study estimated the relative risks of type 1 diabetes immediately after infectious diseases. RESEARCH DESIGN AND METHODS: A case-crossover design was employed. Information on infectious diseases during 407 d before the onset of type 1 diabetes was collected from medical records and parents' interviews for 260 patients in Chinese type 1 diabetes registry. The frequency of infectious diseases in 42 d before the onset of type 1 diabetes was compared with either the usual frequency of infectious diseases over the past year or the actual frequency of infectious diseases in a comparable 42-d control period. RESULTS: Forty-eight (18%) patients were reported to have infectious diseases during this period based on medical records and interviews with parents. The relative risk of type 1 diabetes onset was markedly elevated to 10.1 (5.6, 17.9) immediately after infectious diseases, suggesting the role of infections as a precipitator. The relative risk decreased gradually before and after 42 d and was similar between male and female patients. CONCLUSION: The results showed that infectious diseases are associated with a large and transient increase in the risk of type 1 diabetes during 42 d after the infection.

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CausalityChildChinaCommunicable DiseasesCross-Over StudiesDiabetes Mellitus, Type 1FemaleHumansLogistic ModelsMaleRegistriesResearch DesignRiskJournal Article

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Ze Yang, Fan Zhou, Janice Dorman, Huijuan Wang, Xiaoquan Zu, Sati Mazumdar, Ronald E LaPorte. 2006. Association between infectious diseases and type 1 diabetes: a case-crossover study.. https://doi.org/10.1111/j.1399-543x.2006.00163.x

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