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Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae.

Gili Regev-Yochay·Krzysztof Trzcinski·Claudette M Thompson·Richard Malley·Marc Lipsitch
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Abstract

The bactericidal activity of Streptococcus pneumoniae toward Staphylococcus aureus is mediated by hydrogen peroxide. Catalase eliminated this activity. Pneumococci grown anaerobically or genetically lacking pyruvate oxidase (SpxB) were not bactericidal, nor were nonpneumococcal streptococci. These results provide a possible mechanistic explanation for the interspecies interference observed in epidemiologic studies.

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AntibiosisCatalaseHydrogen PeroxideMicrobial Sensitivity TestsPyruvate OxidaseStaphylococcus aureusStreptococcus pneumoniaeJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't

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Gili Regev-Yochay, Krzysztof Trzcinski, Claudette M Thompson, Richard Malley, Marc Lipsitch. 2006. Interference between Streptococcus pneumoniae and Staphylococcus aureus: In vitro hydrogen peroxide-mediated killing by Streptococcus pneumoniae.. https://doi.org/10.1128/jb.00317-06

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