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PubMed · 1679382

Molecular genetic considerations in osteosarcoma.

M F Hansen
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Abstract

Osteosarcoma tumorigenesis is consistent with a model by which tumorigenesis results if both alleles at the retinoblastoma susceptibility locus (RBI) are altered. Additional genetic evidence strongly suggests that another obligate event in osteosarcoma tumorigenesis is the homozygous alteration of another gene, p53. Both the RB1 gene and p53 have been proposed to act as tumor-suppressor genes, suggesting that, in this instance, tumorigenesis is the result of the loss of gene function of these two genes, rather than a gain of function.

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Base SequenceBlotting, SouthernBone NeoplasmsCausalityChromosome DeletionChromosome MappingGene AmplificationGenes, RetinoblastomaGenes, Tumor SuppressorGenes, p53Genetic VariationHumansModels, GeneticMolecular Sequence DataMutagenesisOsteosarcomaPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthRetinoblastomaTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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M F Hansen. 1991. Molecular genetic considerations in osteosarcoma.. https://pubmed.ncbi.nlm.nih.gov/1679382/

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