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Epinephrine-containing test dose during beta-blockade.

K Mackie·A Lam
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Abstract

Epinephrine is routinely used as a marker for intravascular injection during administration of regional anesthesia. The cardiovascular response of patients on beta-blockers to such a test dose has been reported to be unpredictable. We investigated this interaction by administering 15 micrograms of epinephrine intravenously to 6 healthy volunteers 39 to 48 years old before and after beta-blockade, accomplished by intravenous injection of propranolol, 0.04 mg/kg. Epinephrine administration caused a 20 +/- 4% (mean +/- SEM) increase in heart rate before beta-blockade but a 38 +/- 3% reduction after beta-blockade. The lowest heart rate recorded was 28 beats/min. We conclude that, in middle-aged beta-blocked men, intravenous injection of a standard epinephrine-containing test dose will predictably cause significant hypertension followed by marked bradycardia.

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Adrenergic beta-AntagonistsAdultAnesthesia, ConductionBlood PressureDrug InteractionsEpinephrineHeart RateHumansInjections, IntravenousMaleMiddle AgedPropranololStimulation, ChemicalJournal Article

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K Mackie, A Lam. 1991. Epinephrine-containing test dose during beta-blockade.. https://doi.org/10.1007/bf01619262

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