Oxide hemostatic activity.

Todd A Ostomel; Qihui Shi; Galen D Stucky

doi:10.1021/ja061717a

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Oxide hemostatic activity.

Todd A Ostomel·Qihui Shi·Galen D Stucky

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Abstract

The tunable in vitro blood clotting activity of high-surface-area hemostatic bioactive glass is evaluated by Thromboelastograph, a clinical instrument for quantifying changes in blood during coagulation. The hemostatic trends associated with hemostatic bioactive glass and a new preparation of spherical hemostatic bioactive glass, along with similar Si- and Ca-containing oxides, are described and related to Si:Ca ratios, Ca2+ availability and coordination environment, porosity, DeltaHHydration, and surface area. Hemostatic bioactive glass is a new material with an excellent efficacy for inducing hemostasis and is chemically distinct from the traditional bioglass employed for bone growth.

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Blood Coagulation Calcium Carbonate Calcium Compounds Durapatite Hemostatics Oxides Particle Size Porosity Silicon Dioxide Surface Properties Thrombelastography Time Factors Journal Article Research Support, U.S. Gov't, Non-P.H.S.

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Todd A Ostomel, Qihui Shi, Galen D Stucky. 2006-07-05. Oxide hemostatic activity.. https://doi.org/10.1021/ja061717a

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