Comparative genetic mutation frequencies based on amino acid composition differences.

Amandio Vieira

doi:10.1016/j.mrfmmm.2006.03.009

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Comparative genetic mutation frequencies based on amino acid composition differences.

Amandio Vieira

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Abstract

Genetic variation inferred from large-scale amino acid composition comparisons among genomes and chromosomes of several species, Saccharomyces cerevisiae, Drosophila melanogaster, Ceanorhabditis elegans, H. sapiens, is shown to be correlated (highest, r(2)=0.9855, p<0.01) with reported mutation rates for various genes in these species. This study, based largely on pseudogene data, helps to establish reference mutation frequencies that are likely to be representative of overall genome mutation rates in each of the species examined, and provides further insight into heterogeneity of mutation rates among genomes.

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Amino Acid Sequence Amino Acids Animals Caenorhabditis elegans Databases, Genetic Drosophila melanogaster Humans Mutation Pseudogenes Saccharomyces cerevisiae Comparative Study Journal Article Research Support, Non-U.S. Gov't

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Amandio Vieira. 2006-06-30. Comparative genetic mutation frequencies based on amino acid composition differences.. https://doi.org/10.1016/j.mrfmmm.2006.03.009

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