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[Complement factor I deficiency revealed by repeated systemic Streptococcus pneumoniae infection].

M Monfort-Gouraud·C Vignon·A Vincens·J Blouin·V Frémeaux-Bacchi·P Talon
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Abstract

Recurrent and serious otitis media, and 2 Streptococcus pneumoniae bacteraemia episodes evoked an immune system deficiency in a 6-year-old girl. Upon investigation of the complement system, CH50 activity was moderately reduced and C4 antigen level was normal contrasting with low C3 antigen level. Factor 1 was undetectable. Factor I deficiency is rare, and its diagnosis has important practical consequences. Thanks to preventive antibiotic therapy with penicillin V and vaccinations against Neisseria meningitidis and S. pneumoniae, life expectancy and quality of this child can be significantly improved.

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Anti-Bacterial AgentsBlood Coagulation Disorders, InheritedChildFemaleFibrinogenHumansOtitis MediaPneumococcal InfectionsTreatment OutcomeCase ReportsEnglish AbstractJournal Article

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M Monfort-Gouraud, C Vignon, A Vincens, J Blouin, V Frémeaux-Bacchi, P Talon. 2006-06-27. [Complement factor I deficiency revealed by repeated systemic Streptococcus pneumoniae infection].. https://doi.org/10.1016/j.arcped.2006.04.023

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