Nuclear reprogramming and pluripotency.

Konrad Hochedlinger; Rudolf Jaenisch

doi:10.1038/nature04955

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Nuclear reprogramming and pluripotency.

Konrad Hochedlinger·Rudolf Jaenisch

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Abstract

The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic stem cells by nuclear transfer underscores the potential use of this technology in regenerative medicine. The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes.

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Animals Cell Fusion Cell Nucleus Cloning, Organism Humans Nuclear Transfer Techniques Pluripotent Stem Cells Regenerative Medicine Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Konrad Hochedlinger, Rudolf Jaenisch. 2006-06-29. Nuclear reprogramming and pluripotency.. https://doi.org/10.1038/nature04955

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