Interactions between alcohol and gastric metabolizing enzymes: practical implications.

J Caballería

PubMed · 1682046

Interactions between alcohol and gastric metabolizing enzymes: practical implications.

Abstract

It has been demonstrated recently that some portion of ingested alcohol does not enter the systemic circulation and is not retained in the gastrointestinal tract; instead, gastric oxidation or first-pass metabolism of ethanol occurs in the stomach, catalyzed by gastric alcohol dehydrogenase. First-pass metabolism of ethanol is minimal in the fasting state; it is lower in women than in men, and in alcoholics than in nonalcoholics; and it is abolished in patients after subtotal gastrectomy. In addition, some drugs may affect first-pass ethanol metabolism. Studies of the effects of H2-receptor antagonists on blood ethanol levels are reviewed. It is concluded that some H2-receptor antagonists (cimetidine and nizatidine, in particular) can inhibit gastric ethanol oxidation and thus increase blood alcohol levels after drinking. The clinical and medicolegal implications of these findings are discussed.

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Alcohol Dehydrogenase Animals Biological Availability Ethanol Gastric Mucosa Histamine H2 Antagonists Humans Isoenzymes Rats Stomach Comparative Study Journal Article Review

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J Caballería. Interactions between alcohol and gastric metabolizing enzymes: practical implications.. https://pubmed.ncbi.nlm.nih.gov/1682046/

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