Stochastically driven genetic circuits.

L S Tsimring; D Volfson; J Hasty

doi:10.1063/1.2209571

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PubMed · 16822035

Stochastically driven genetic circuits.

L S Tsimring·D Volfson·J Hasty

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Abstract

Transcriptional regulation in small genetic circuits exhibits large stochastic fluctuations. Recent experiments have shown that a significant fraction of these fluctuations is caused by extrinsic factors. In this paper we review several theoretical and computational approaches to modeling of small genetic circuits driven by extrinsic stochastic processes. We propose a simplified approach to this problem, which can be used in the case when extrinsic fluctuations dominate the stochastic dynamics of the circuit (as appears to be the case in eukaryots). This approach is applied to a model of a single nonregulated gene that is driven by a certain gating process that affects the rate of transcription, and to a simplified version of the galactose utilization circuit in yeast.

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Animals Cell Physiological Phenomena Computer Simulation Fourier Analysis Gene Expression Genetic Variation Humans Models, Genetic Models, Statistical Nonlinear Dynamics Protein Biosynthesis Signal Transduction Stochastic Processes Transcription Factors Transcription, Genetic Journal Article Research Support, N.I.H., Extramural

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L S Tsimring, D Volfson, J Hasty. 2006. Stochastically driven genetic circuits.. https://doi.org/10.1063/1.2209571

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