TGF-beta receptor-binding proteins: complex interactions.

Constance E Runyan; Anne-Christine Poncelet; H William Schnaper

doi:10.1016/j.cellsig.2006.05.009

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TGF-beta receptor-binding proteins: complex interactions.

Constance E Runyan·Anne-Christine Poncelet·H William Schnaper

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Abstract

Members of the Smad protein family are fundamental downstream mediators of TGF-beta signals. However, the basic, linear Smad signaling pathway is unlikely to be the sole contributor to the plethora of cell type-specific TGF-beta responses. Investigators have identified a number of molecules that interact with the TGF-beta receptors (TbetaRs) and may explain, at least in part, the tight regulation of TGF-beta effects. Understanding these TbetaR-interacting molecules is thus a matter of great potential significance for elucidating TGF-beta-family signal transduction. The present article reviews our current understanding of the roles and mechanisms of action of this relatively understudied group of molecules.

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Animals Gene Expression Humans Models, Biological Protein Binding Receptors, Transforming Growth Factor beta Signal Transduction Smad Proteins Journal Article Research Support, N.I.H., Extramural

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Constance E Runyan, Anne-Christine Poncelet, H William Schnaper. 2006-05-23. TGF-beta receptor-binding proteins: complex interactions.. https://doi.org/10.1016/j.cellsig.2006.05.009

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