PubMed Health⌕ Search

PubMed · 16832669

Temporal lobe resections.

Abstract

INTRODUCTION: In the 50 years since Penfield outlined the requirements of the epilepsy surgeon, we have seen the introduction of the digitised electroencephalogram (EEG), video telemetry and the magnetic resonance imaging (MRI) scan. In the operating room, advances in neuro-anaesthesia, the introduction of the operating microscope, image guidance and the ultrasonic aspirator have greatly enhanced the surgeons' technical ability. Despite these changes, the thesis encapsulated in Penfield's statement is that the surgeon needs to understand and interpret the preoperative data in such a way as to identify as closely as possible the epileptogenic zone where he must carry out surgery with the utmost care and diligence, and finally, in the context of audit and follow-up of his surgical patients, he must be able to predict for each individual case the likelihood of success and failure of any particular procedure. CONCLUSION: Previous articles in this supplement have looked at the specific investigations carried out to identify the epileptogenic zone, but once this data has been gathered, it is the responsibility of the neurosurgeon, within the context of the multidisciplinary team, to decide whether surgery is both feasible and advisable and then to discuss this in depth with the patient and their family and carers. The multidisciplinary epilepsy surgery meeting allows cases to be discussed in an open forum and the decisions made in this meeting can then be discussed with the family. The process of consent will begin from the moment any surgical procedure is discussed and should, wherever possible, be reinforced with written, as well as verbal, information. The process of consent should be a continuum until the actual day of surgery. All parties involved in the care and management of the patient should be regarded as stakeholders in this decision, and it is vital that all these stakeholders are working towards a common goal. OBJECTIVES: In this article, I will consider the specific aspects of the presurgical investigations that are applicable to the temporal lobe and the differing types of surgery that are likely to be indicated. I will then describe, in detail, the surgical technique of temporal lobe resection, highlighting some of the pitfalls and successes that such surgery can provide.

Explore related subjects

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

William Harkness. 2006-07-11. Temporal lobe resections.. https://doi.org/10.1007/s00381-006-0140-5

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

THE SCN2A gene is not a likely candidate for familial mesial temporal lobe epilepsy.

A transgenic mouse model carrying a mutation in the Scn2a gene showed chronic focal seizures associated with extensive cell loss and gliosis in the hippocampus, a similar phenotype found in familial mesial temporal lobe epilepsy (FMTLE). Our objective was to test whether the human homolog of the Scn2a gene is responsible for hippocampal abnormalities in FMTLE by linkage analysis. We conclusively ruled out the SCN2A gene as candidate in FMTLE.

Epilepsy, Temporal Lobe↗

Epileptic polyopia with right temporal lobe epilepsy as studied by FDG-PET and MRI: a case report.

Polyopia is one of rare, visual hallucinations. A 61-year-old man suffered from daily episodes of polyopia and generalized convulsions, and he was diagnosed as right temporal lobe epilepsy. MRI revealed right amygdalar swelling. FDG-PET showed hypometabolism in the right anterior temporal and the mesial occipital areas. Polyopia is thought to be caused by dysfunction of updating process of visual information in the visual association cortices. It was most likely that, in this patient, both mesial temporal and ipsilateral occipital areas were responsible for manifesting epileptic polyopia, as ictal onset zone and symptomatogenic zone, respectively.

Epilepsy, Temporal Lobe↗

Neurocysticercosis and microscopic hippocampal dysplasia in a patient with refractory mesial temporal lobe epilepsy.

Epidemiologic studies suggest that neurocysticercosis (NC) is the main cause of symptomatic epilepsy in developing countries. The association between NC and mesial temporal lobe epilepsy (MTLE) has been reported by several authors. Recent data have shown that the presence of NC does not influence the clinical and pathological profile in MTLE patients and suggest that not all cysticercotic lesions are inevitably epileptogenic. We describe a 50-years-old woman with partial seizures due to NC which evolve to MTLE. The patient was submitted to a corticoamygdalohippocampectomy to treat refractory epilepsy. An immunohistochemical study using neuronal markers was made on hippocampal formation. Besides the typical aspects of Ammon's horn sclerosis (AHS), the microscopic examination demonstrates cellular features of hippocampal malformation including dysmorphic neurons and focal bilamination of granular cell layer. We suggest that, in this case, a developmental disorder lowered the threshold for the NC-induced seizures and contributed to the establishment of refractory epilepsy.

Epilepsy, Temporal Lobe↗