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Human neuroblastoma stem cells.

Robert A Ross·Barbara A Spengler
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Abstract

Human neuroblastoma is an embryonic cancer of the neural crest. Cellular heterogeneity is a characteristic feature of both tumors and derived cell lines. Recent studies have revealed that both cell lines and tumors contain cancer stem cells. In culture, these cells are self-renewing, multipotent, and highly malignant; in tumors their frequency correlates with a worse prognosis. Their identification and characterization should now permit a targeted approach to more effective treatment of this often fatal childhood cancer.

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HumansNeoplastic Stem CellsNeural CrestNeuroblastomaJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReview

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Robert A Ross, Barbara A Spengler. 2006-05-17. Human neuroblastoma stem cells.. https://doi.org/10.1016/j.semcancer.2006.04.006

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