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It takes a PHD to read the histone code.

Jane Mellor
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Abstract

The pattern of histone modifications, called the histone code, influences transitions between chromatin states and the regulation of transcriptional activity. Four recent papers describe how plant homeodomain (PHD) finger proteins read part of this code. The PHD finger may promote both gene expression and repression through interactions with trimethylated lysine 4 on histone 3 (H3K4), a universal modification at the beginning of active genes.

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ChromatinGene Expression Regulation, PlantHistonesHomeodomain ProteinsModels, MolecularPlant ProteinsProtein Structure, TertiaryRepressor ProteinsJournal ArticleReview

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Jane Mellor. 2006-07-14. It takes a PHD to read the histone code.. https://doi.org/10.1016/j.cell.2006.06.028

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