Is methylglyoxal a causative factor for hypertension development?

Lingyun Wu

doi:10.1139/y05-137

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Is methylglyoxal a causative factor for hypertension development?

Lingyun Wu

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Abstract

Hypertension is a life-threatening disease that is associated with increased cardiovascular risks. Causes and mechanisms for hypertension development remain poorly understood. Methylglyoxal (MG), a highly reactive molecule, is a metabolite of sugar. Increased circulation and tissue levels of MG have been documented not only in diabetes but also in hypertension. Many recent studies also link MG-induced vascular damage to the pathogenic process of hypertension. As such, an etiological role of MG in hypertension development is proposed.

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Animals Glucose Humans Hypertension Hypertrophy Mitogen-Activated Protein Kinases Muscle, Smooth, Vascular NF-kappa B Pyruvaldehyde Reactive Oxygen Species Journal Article Research Support, Non-U.S. Gov't Review

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Lingyun Wu. 2006. Is methylglyoxal a causative factor for hypertension development?. https://doi.org/10.1139/y05-137

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