Graded ephrin-A2 expression in the developing hamster superior colliculus.

Sherralee S Lukehurst; Carolyn E King; Lyn D Beazley; David K C Tay; Kwok-Fai So; Jennifer Rodger

doi:10.1007/s00221-006-0615-3

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Graded ephrin-A2 expression in the developing hamster superior colliculus.

Sherralee S Lukehurst·Carolyn E King·Lyn D Beazley·David K C Tay·Kwok-Fai So·Jennifer Rodger

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Abstract

During development, ephrin gradients guide retinal ganglion cell axons to their appropriate topographic locations in the superior colliculus (SC). Expression of ephrin-A2, assessed immunohistochemically in the developing hamster SC, revealed a rostral(low) to caudal (high) gradient that is most prominent at postnatal days P4 and P7 when topography is established. Double-labelling immunohistochemistry for ephrin-A2 and cell specific markers revealed that ephrin-A2 is expressed exclusively by a subset of neurons. The expression pattern has implications for mechanisms underlying establishment of topography during development and following injury.

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Animals Astrocytes Cell Count Cricetinae Ephrin-A2 Fluorescent Antibody Technique, Indirect Immunohistochemistry Microscopy, Confocal Retina Retinal Ganglion Cells Superior Colliculi Journal Article Research Support, Non-U.S. Gov't

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Sherralee S Lukehurst, Carolyn E King, Lyn D Beazley, David K C Tay, Kwok-Fai So, Jennifer Rodger. 2006-07-19. Graded ephrin-A2 expression in the developing hamster superior colliculus.. https://doi.org/10.1007/s00221-006-0615-3

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