Abnormalities in central auditory maturation in children with language-based learning problems.

Phillip M Gilley; Anu Sharma; Michael Dorman; Kathryn Martin

doi:10.1016/j.clinph.2006.05.015

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Abnormalities in central auditory maturation in children with language-based learning problems.

Phillip M Gilley·Anu Sharma·Michael Dorman·Kathryn Martin

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Abstract

OBJECTIVE: To examine maturation of the central auditory pathways in children with language-based learning problems (LP). METHODS: Cortical auditory evoked potentials (CAEPs) recorded from 26 children with LP were compared to CAEPs recorded from 38 typical children. CAEP responses were recorded in response to a speech sound, /uh/, which was presented in a stimulus train with decreasing inter-stimulus intervals (ISIs) of 2000, 1000, 560, and 360 ms. RESULTS: We identified three atypical morphological categories of CAEP responses in the LP group. Category 1 responses revealed delayed P1 latencies and absent N1/P2 components. Category 2 responses revealed typical P1 responses, but delayed N1 and P2 responses. Category 3 responses revealed generally low-amplitude CAEP responses. A fourth sub-group of LP children had normal CAEP responses. CONCLUSIONS: Overall, the majority of children with LP had abnormal CAEP responses. These children fell into distinct categories based on the abnormalities in maturational patterns of their CAEP responses. SIGNIFICANCE: We describe a rate sensitive stimulation paradigm which may be used to identify and categorize LP children who exhibit abnormal patterns of central auditory maturation.

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Acoustic Stimulation Adolescent Age Factors Auditory Cortex Child Child Development Electroencephalography Evoked Potentials, Auditory Female Humans Language Disorders Learning Disabilities Male Time Factors Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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Phillip M Gilley, Anu Sharma, Michael Dorman, Kathryn Martin. 2006-07-18. Abnormalities in central auditory maturation in children with language-based learning problems.. https://doi.org/10.1016/j.clinph.2006.05.015

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