TLR gateways to CD1 function.

D Branch Moody

doi:10.1038/ni1368

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PubMed · 16855607

TLR gateways to CD1 function.

D Branch Moody

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Abstract

CD1-restricted T cells can be activated by diverse lipids derived from mammals, bacteria and protozoa. Certain lipids function as antigens, which bind to CD1 proteins and contact T cell antigen receptors. Other lipids activate CD1-restricted T cells by functioning as adjuvants. By stimulating Toll-like receptors on antigen-presenting cells, these adjuvants alter cytokine secretion, lipid antigen synthesis and CD1 protein translation. Delineation of the separate mechanisms by which adjuvants and antigens activate CD1-restricted T cells is leading to new hypotheses about the functions of individual CD1 proteins during the transition from innate to acquired immune responses.

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Adjuvants, Immunologic Animals Antigen Presentation Antigens Antigens, CD1 Humans Lipids Lymphocyte Activation T-Lymphocytes Toll-Like Receptors Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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D Branch Moody. 2006. TLR gateways to CD1 function.. https://doi.org/10.1038/ni1368

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