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PubMed · 16855849

[Antibiotic therapy for exacerbation].

K Dalhoff·H Kothe
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Abstract

Bacterial infections are involved in approximately 50% of acute exacerbations of chronic bronchitis (AECB). Pneumococci, Haemophilus influenzae and Moraxella catarrhalis are the main pathogens. Studies using quantitative cultures and molecular typing suggest a causal relationship between bacterial infection and exacerbation. Furthermore, an association between infection and bronchial inflammation has been demonstrated. In contrast to steroid therapy and non-invasive ventilation, the benefits of antibiotic treatment are not well established. Current guidelines recommend antimicrobial therapy for AECB in type I exacerbations, for patients needing ventilatory support and for patients with cardiac comorbidity. Bacterial eradication is able to prolong the infection free interval.

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Anti-Bacterial AgentsBacterial InfectionsBronchitisDisease ProgressionDrug Therapy, CombinationForced Expiratory VolumeHumansInflammation MediatorsMicrobial Sensitivity TestsPneumonia, BacterialPulmonary Disease, Chronic ObstructiveSputumEnglish AbstractJournal ArticleReview

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K Dalhoff, H Kothe. 2006. [Antibiotic therapy for exacerbation].. https://doi.org/10.1007/s00108-006-1687-7

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