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NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.

Alain Israël
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Abstract

Non-degradative ubiquitination events have been recently demonstrated to have an important role in activating the IkappaB kinase (IKK) complex, the central component of the nuclear factor (NF)-kappaB signaling cascade. Two new papers demonstrate that NF-kappaB essential modulator (NEMO)-IKKgamma, the structural and regulatory component of the IKK complex, specifically recognizes Lys63 polyubiquitin chains attached to the receptor-interacting protein (RIP)1 kinase following tumor necrosis factor treatment, and that this recognition is a requirement for IKK activation.

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Enzyme ActivationI-kappa B KinaseNF-kappa BUbiquitinsJournal Article

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Alain Israël. 2006-07-18. NF-kappaB activation: Nondegradative ubiquitination implicates NEMO.. https://doi.org/10.1016/j.it.2006.07.003

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