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PubMed · 16857582

DNA replication: keep moving and don't mind the gap.

Lance D Langston·Mike O'Donnell
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Abstract

As the replication fork progresses, synthesis of the discontinuous lagging strand requires frequent priming and cycling of the lagging strand polymerase to the new primers. It appears that this mechanism also permits bypass of template lesions on both strands, leaving the damage behind in a single-strand gap and precluding fork stalling or collapse.

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DNA ReplicationDNA-Directed DNA PolymeraseEscherichia coliEukaryotic CellsMultienzyme ComplexesReplisomesJournal ArticleReview

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Lance D Langston, Mike O'Donnell. 2006-07-21. DNA replication: keep moving and don't mind the gap.. https://doi.org/10.1016/j.molcel.2006.05.034

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