New perspectives in B-1 B cell development and function.

Encarnacion Montecino-Rodriguez; Kenneth Dorshkind

doi:10.1016/j.it.2006.07.005

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PubMed · 16861037

New perspectives in B-1 B cell development and function.

Encarnacion Montecino-Rodriguez·Kenneth Dorshkind

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Abstract

In contrast to the predominant population of B-2 B cells produced in the bone marrow, B-1 B cells are a minor population of B lymphocytes that are found in multiple tissues, including the pleural and peritoneal cavities in mice. Although the role of B-1 B cells as effectors of innate-like immunity is widely accepted, their developmental origin has been controversial. This review highlights recent experimental data from murine studies supporting the hypothesis that B-1 B cells belong to a developmental lineage distinct from B-2 B cells, and draws attention to recent studies that have defined new roles for the B-1a and B-1b B-cell subsets in the response to bacteria and self-antigens.

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Animals B-Lymphocytes Humans Mice Journal Article Research Support, N.I.H., Extramural Review

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Encarnacion Montecino-Rodriguez, Kenneth Dorshkind. 2006-07-24. New perspectives in B-1 B cell development and function.. https://doi.org/10.1016/j.it.2006.07.005

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