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A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model.

Ming-Cai Zhang·Shiro Mori·Fumiko Date·Hiroshi Furukawa·Masao Ono
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Abstract

BACKGROUND: The incidence and characteristics of spontaneous ankylosis in the ankle of specific F(1) mice descended from two Fas-deficient strains were reported. Here the coincidence of synovial proliferation and ankylosis in the descendent F(2) mice is reported. AIM: To clarify whether the two distinct manifestations are genetically different. METHODS: An arthropathic group of mice (MCF(2)) were bred by intercrossing MRL/Mp.Fas(lpr)-sap(-)/sap(-) and C3H/He.Fas(lpr) mice. All mice were killed by bleeding under anaesthesia when they were 6 months old. Pathological grades for synovial proliferation were determined by microscopical examination. To obtain a linkage locus, the whole genome of male MCF(2) mice was scanned by using 73 microsatellite markers. RESULTS: Synovial proliferation was equally observed in male and female MCF(2) mice. No correlation was observed between the grades of synovial proliferation and the ankylosis occurring in the MCF(2) mice. A suggestive susceptibility locus was shown in the middle of chromosome 11. This locus was an MRL allele with a recessive inheritance mode. CONCLUSION: The pathogenic mechanisms of synovial proliferation and ankylosis are genetically different. The present locus is overlapped with some loci associated with rheumatoid arthritis and with others associated with experimental arthritides.

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AnimalsBreedingCell ProliferationChromosomes, MammalianDisease Models, AnimalFemaleGenetic Predisposition to DiseaseGenotypeHistocytochemistryJoint DiseasesMaleMiceMice, Inbred C3HMice, Inbred MRL lprMice, Mutant StrainsMicrosatellite RepeatsRheumatic DiseasesSynovial MembraneJournal ArticleResearch Support, Non-U.S. Gov't

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Ming-Cai Zhang, Shiro Mori, Fumiko Date, Hiroshi Furukawa, Masao Ono. 2006-07-25. A non-major histocompatibility locus determines tissue specificity in the pathogenic process underlying synovial proliferation in a mouse arthropathy model.. https://doi.org/10.1136/ard.2006.054999

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