Rho kinase: a target for treating urinary bladder dysfunction?

Stephan L M Peters; Martina Schmidt; Martin C Michel

doi:10.1016/j.tips.2006.07.002

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Rho kinase: a target for treating urinary bladder dysfunction?

Stephan L M Peters·Martina Schmidt·Martin C Michel

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Abstract

Urinary incontinence and other urinary storage symptoms are frequent in the general population but available treatments have limited efficacy and tolerability. Rho kinase (ROCK) has a central role in the regulation of smooth muscle contraction, including that of the urinary bladder. Recent experimental evidence indicates that this role could be deregulated and exacerbated in local and systemic pathological conditions that affect the bladder. In vitro studies with prototypical ROCK inhibitors such as Y27632 and in vivo data from animal models indicate that such drugs have potential as future treatments for bladder dysfunction.

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Animals Diabetes Complications Enzyme Activation Enzyme Inhibitors Humans Hypertension Hypertrophy Intracellular Signaling Peptides and Proteins Muscle Contraction Protein Serine-Threonine Kinases Urinary Bladder Urinary Bladder Diseases rho-Associated Kinases Journal Article Review

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Stephan L M Peters, Martina Schmidt, Martin C Michel. 2006-07-25. Rho kinase: a target for treating urinary bladder dysfunction?. https://doi.org/10.1016/j.tips.2006.07.002

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