Regulating secretory lysosomes.

Oliver J Holt; Federico Gallo; Gillian M Griffiths

doi:10.1093/jb/mvj126

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Regulating secretory lysosomes.

Oliver J Holt·Federico Gallo·Gillian M Griffiths

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Abstract

Secretory lysosomes are lysosomes which are capable of undergoing regulated secretion in response to external stimuli. Many cells of the immune system use secretory lysosomes to release proteins involved in their specialised effector mechanisms. Precisely how lysosomal secretion is regulated in each of these cell types is now the study of much research as these mechanisms control the ability of each of these cells to function. Studies on a number of human genetic diseases have identified some key proteins in controlling secretory lysosome release, and now many interacting partners have been identified. The different regulatory components seem to vary from one cell type to another, providing a multitude of ways for fine tuning the release of secretory lysosomes.

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Adaptor Protein Complex 3 Alkyl and Aryl Transferases Animals Chediak-Higashi Syndrome Hermanski-Pudlak Syndrome Humans Lysosomes Membrane Fusion Membrane Proteins Nerve Tissue Proteins SNARE Proteins T-Lymphocytes, Cytotoxic Vesicular Transport Proteins rab GTP-Binding Proteins rab27 GTP-Binding Proteins Journal Article Review

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Oliver J Holt, Federico Gallo, Gillian M Griffiths. 2006. Regulating secretory lysosomes.. https://doi.org/10.1093/jb%2Fmvj126

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