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Cell-cell communication in Gram-negative bacteria.

Martin Welch·Helga Mikkelsen·Jane E Swatton·Debra Smith·Gemma L Thomas·Freija G Glansdorp·David R Spring
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Abstract

Over the last decade or so, a wealth of research has established that bacteria communicate with one another using small molecules. These signals enable the individuals in a population to coordinate their behaviour. In the case of pathogens, this behaviour may include decisions such as when to attack a host organism or form a biofilm. Consequently, such signalling systems are excellent targets for the development of new antibacterial therapies. In this review, we assess how Gram-negative bacteria use small molecules for cell-cell communication, and discuss the main approaches that have been developed to interfere with it.

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Cell CommunicationGram-Negative BacteriaVirulenceJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Martin Welch, Helga Mikkelsen, Jane E Swatton, Debra Smith, Gemma L Thomas, Freija G Glansdorp, David R Spring. 2005-07-25. Cell-cell communication in Gram-negative bacteria.. https://doi.org/10.1039/b505796p

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