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Clues to VIP function from knockout mice.

S A Hamidi·A M Szema·S Lyubsky·K G Dickman·A Degene·S M Mathew·J A Waschek·S I Said
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Abstract

We have taken advantage of the availability of vasoactive intestinal polypeptide (VIP) knockout (KO) mice to examine the possible influence of deletion of the VIP gene on: (a) airway reactivity and airway inflammation, as indicators of bronchial asthma; (b) mortality from endotoxemia, a model of septic shock; and (c) the pulmonary circulation. VIP KO mice showed: (a) airway hyperresponsiveness to the cholinergic agonist methacholine, as well as peribronchial and perivascular inflammation; (b) a greater susceptibility to death from endotoxemia; and (c) evidence suggestive of pulmonary hypertension.

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AnimalsBronchitisDisease SusceptibilityEndotoxemiaFemaleLipopolysaccharidesMaleMethacholine ChlorideMiceMice, Inbred C57BLMice, KnockoutSurvival RateVasoactive Intestinal PeptideJournal Article

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BibTeXRIS

S A Hamidi, A M Szema, S Lyubsky, K G Dickman, A Degene, S M Mathew, J A Waschek, S I Said. 2006. Clues to VIP function from knockout mice.. https://doi.org/10.1196/annals.1317.035

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