The A-minor motifs in the decoding recognition process.

A Lescoute; E Westhof

doi:10.1016/j.biochi.2006.05.018

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The A-minor motifs in the decoding recognition process.

A Lescoute·E Westhof

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Abstract

The formation of A-minor motifs, mediated by adenines binding into the shallow/minor groove of stacked and helical Watson-Crick base pairs, is described. The conformations of the bacterial ribosomal decoding A site in various crystal structures are reviewed. The adenines A1492 and A1493 of the A site are seen either tucked in within the internal loop or bulging out and poised for interaction. This dynamic equilibrium contributes to the decoding process of the codon:anticodon base pairings. Aminoglycoside antibiotics lock the conformation of the A site in a single state with bulged-out adenines and thereby disrupt regulation of the decoding process.

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Adenine Anti-Bacterial Agents Anticodon Base Pairing Binding Sites Codon Nucleic Acid Conformation RNA, Ribosomal Ribosomes Thermodynamics Journal Article Review

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A Lescoute, E Westhof. 2006-06-19. The A-minor motifs in the decoding recognition process.. https://doi.org/10.1016/j.biochi.2006.05.018

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