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PubMed · 16890440

Non-coding RNA in fly dosage compensation.

Xinxian Deng·Victoria H Meller
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Abstract

Dosage compensation modulates global expression of an X chromosome and is necessary to restore the balance between X-chromosome and autosome expression in both sexes. A central question in the field is how this regulation is directed. Large non-coding RNAs, such as Xist in mammals and roX in flies, have pivotal roles in targeting chromosome-wide modification for dosage compensation. Several recent studies in Drosophila provide new insight into the principles of X-chromosome recognition and the function of non-coding RNA in this process.

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AnimalsDosage Compensation, GeneticDrosophila ProteinsDrosophila melanogasterHumansModels, BiologicalRNA, Long NoncodingRNA, UntranslatedTranscription FactorsX ChromosomeX Chromosome InactivationJournal ArticleReview

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Xinxian Deng, Victoria H Meller. 2006-08-04. Non-coding RNA in fly dosage compensation.. https://doi.org/10.1016/j.tibs.2006.07.007

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