PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 16891378

The hidden value of missing genotypes.

William Amos
View original source ↗Export metadata ↓

Abstract

Robotic systems allow vast genetic data sets to be generated automatically with little manual input, raising questions about accuracy. To test whether errors occur randomly, I used the frequencies of missing genotypes in a large human data set to construct a population tree. Remarkably, the gaps appear to carry as strong a phylogenetic signal as the actual data themselves.

Explore related subjects

Data CollectionDatabases, GeneticGenotypeHumansMicrosatellite RepeatsPhylogenyPopulation GroupsResearch DesignLetter

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

William Amos. 2006-08-04. The hidden value of missing genotypes.. https://doi.org/10.1093/molbev%2Fmsl078

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed2007

Probability estimation when some observations are grouped.

This paper considers the use of additional questions for decreasing survey non-response rates and an approach for estimating a probability based on the results obtained. In a survey, the respondents are asked to answer an original question and follow-up questions, where the answers for the follow-up questions are grouped answers for the original question. For example, respondents are asked to provide an exact number of incidents, but in cases of 'Do not know' or 'Refuse' responses, they are subsequently asked to pick an answer from a less specific categorical scale. The new estimator obtains smaller variance asymptotically and does not depend on a distribution family. This method is applied to income questions in a survey regarding injury prevention and behaviours. Another application is survey data on intimate partner violence, where some amendments were applied for incorporating post-stratification weights and for using non-random grouping. For additional illustration, an example of parameter estimation on artificially generated data is presented.

Data Collection↗