Chromatin modulation and the DNA damage response.

Thomas Costelloe; Jennifer Fitzgerald; Niall J Murphy; Andrew Flaus; Noel F Lowndes

doi:10.1016/j.yexcr.2006.06.031

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Chromatin modulation and the DNA damage response.

Thomas Costelloe·Jennifer Fitzgerald·Niall J Murphy·Andrew Flaus·Noel F Lowndes

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Abstract

The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.

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Acetylation Animals Chromatin Chromatin Assembly and Disassembly DNA Damage DNA Repair Histones Humans Methylation Models, Genetic Models, Molecular Phosphorylation Protein Processing, Post-Translational Journal Article Research Support, Non-U.S. Gov't Review

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Thomas Costelloe, Jennifer Fitzgerald, Niall J Murphy, Andrew Flaus, Noel F Lowndes. 2006-06-30. Chromatin modulation and the DNA damage response.. https://doi.org/10.1016/j.yexcr.2006.06.031

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