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PubMed · 1689594

Percolation model of ionic channel dynamics.

W Doster·W Schirmacher·M Settles
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Abstract

The nonexponential closed-time distributions observed for ionic channels have been explained recently by quasi-one-dimensional models of structural diffusion (Millhauser, G. L., E. E. Salpeter, and R. E. Oswald. 1988. Proc. Natl. Acad. Sci. USA. 85: 1503-1507; Condat, C. A., and J. Jäckle. 1989. Biophys. J. 55: 915-925; Levitt, D. G. 1989. Biophys. J. 55: 489-498). We generalize this treatment by allowing for more complex trajectories using percolation theory. We assume that the gating transition depends on marginally connected conformational states leading to the observed spread in time scales.

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Computer SimulationDiffusionHydrogen BondingIon ChannelsMathematicsModels, BiologicalJournal ArticleResearch Support, Non-U.S. Gov't

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W Doster, W Schirmacher, M Settles. 1990. Percolation model of ionic channel dynamics.. https://doi.org/10.1016/s0006-3495(90)82588-1

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