Synaptic plasticity and phosphorylation.

Hey-Kyoung Lee

doi:10.1016/j.pharmthera.2006.06.003

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Synaptic plasticity and phosphorylation.

Hey-Kyoung Lee

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Abstract

A number of neuronal functions, including synaptic plasticity, depend on proper regulation of synaptic proteins, many of which can be rapidly regulated by phosphorylation. Neuronal activity controls the function of these synaptic proteins by exquisitely regulating the balance of various protein kinase and protein phosphatase activity. Recent understanding of synaptic plasticity mechanisms underscores important roles that these synaptic phosphoproteins play in regulating both pre- and post-synaptic functions. This review will focus on key postsynaptic phosphoproteins that have been implicated to play a role in synaptic plasticity.

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Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 Calcium-Calmodulin-Dependent Protein Kinases Humans Neurogranin Neuronal Plasticity Phosphoprotein Phosphatases Phosphoproteins Phosphorylation Protein Kinases Receptors, AMPA Receptors, Glutamate Receptors, N-Methyl-D-Aspartate Synapses Journal Article Review

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Hey-Kyoung Lee. 2006-08-14. Synaptic plasticity and phosphorylation.. https://doi.org/10.1016/j.pharmthera.2006.06.003

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