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PubMed · 16907955

Synthetic prions.

M Eiden·A Buschmann·L Kupfer·M H Groschup
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Abstract

The prion theory postulates that prions are novel infectious agents that are composed largely, if not entirely, of abnormally folded host-encoded prion proteins. However, the existence of different prion strains is enigma, if these novel infectious agents lack a genetic element, such as a nucleic acid. The best proof for this 'protein-only' concept would be the in vitro generation of prions from synthetic sources. Indeed, a substantial body of evidence has meanwhile been accumulated in favour of this postulate. This mini review recapitulates all relevant studies and experimental data on the generation of synthetic prions.

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M Eiden, A Buschmann, L Kupfer, M H Groschup. 2006. Synthetic prions.. https://doi.org/10.1111/j.1439-0450.2006.00966.x

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