Clinical observations with AN-1792 using TAPIR analyses.

Christoph Hock; Roger M Nitsch

doi:10.1159/000090368

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Clinical observations with AN-1792 using TAPIR analyses.

Christoph Hock·Roger M Nitsch

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Abstract

Clinical observations with AN-1792 using tissue amyloid plaque immunoreactivity (TAPIR) analyses established for the first time evidence in humans that antibodies against beta-amyloid-related epitopes are capable of slowing progression in Alzheimer's disease. Antibodies derived upon TAPIR assay selection may specifically target the pathologic neoepitopes of aggregated A beta species present in amyloid plaques and some of their aggregated, protofibrillar and low molecular weight oligomeric precursors. We briefly summarize here how the proof of concept was established and why it provides the basis for a potential cure for Alzheimer's disease.

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Alzheimer Disease Alzheimer Vaccines Amyloid beta-Peptides Antibody Formation Brain Clinical Trials as Topic Disease Progression Hippocampus Humans Magnetic Resonance Imaging Plaque, Amyloid Journal Article Research Support, Non-U.S. Gov't Review

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Christoph Hock, Roger M Nitsch. 2005. Clinical observations with AN-1792 using TAPIR analyses.. https://doi.org/10.1159/000090368

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