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Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.

J M Leung·L P Sands·M Rico·K L Petersen·M C Rowbotham·J B Dahl·C Ames·D Chou·P Weinstein
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Abstract

In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.

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AminesAnalgesicsCyclohexanecarboxylic AcidsDeliriumFeasibility StudiesFemaleGabapentinHumansMaleMiddle AgedNeurosurgical ProceduresPain MeasurementPostoperative PainPilot ProjectsPlacebo EffectPremedicationSpineTreatment Outcomegamma-Aminobutyric AcidJournal ArticleRandomized Controlled TrialResearch Support, N.I.H., Extramural

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BibTeXRIS

J M Leung, L P Sands, M Rico, K L Petersen, M C Rowbotham, J B Dahl, C Ames, D Chou, P Weinstein. 2006-08-16. Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.. https://doi.org/10.1212/01.wnl.0000233831.87781.a9

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