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HIV-1 load quantitation: a 17-year perspective.

Mark Holodniy
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Abstract

During the past decade and a half, quantitation of plasma-associated human immunodeficiency virus type 1 (HIV-1) RNA level, or HIV-1 load, has been validated in clinical practice and clinical trials as an important surrogate marker of HIV-1 disease progression and of the potency and durability of antiretroviral regimens. This review highlights some of the history, accomplishments, and impact of Tom Merigan's laboratory on the use of HIV-1 load as a marker, as well as on updating technologies for determining HIV-1 load, their performance, interpretation of the results, and their use in clinical practice.

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Anti-HIV AgentsBiomarkersDisease ProgressionHIV InfectionsHIV-1HumansRNA, ViralViral LoadJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Review

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Mark Holodniy. 2006-09-15. HIV-1 load quantitation: a 17-year perspective.. https://doi.org/10.1086/505352

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