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Structure and function of nucleosome assembly proteins.

Young-Jun Park·Karolin Luger
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Abstract

Homologues of nucleosome assembly protein 1 (NAP1) have been identified in all eukaryotes. Although initially identified as histone chaperones and chromatin-assembly factors, additional functions include roles in tissue-specific transcription regulation, apoptosis, histone shuttling, and cell-cycle regulation, and extend beyond those of a simple chaperone and assembly factor. NAP1 family members share a structurally conserved fold, the NAP domain. Here we review current knowledge of the NAP family of proteins within the context of the recently determined crystal structure of the NAP1 family's first representative, NAP1 from yeast.

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Active Transport, Cell NucleusAnimalsApoptosisCell CycleCell Cycle ProteinsChromatin Assembly and DisassemblyHumansMaleModels, BiologicalMolecular ChaperonesMultigene FamilyNuclear ProteinsNucleosome Assembly Protein 1Protein Structure, TertiarySignal TransductionTranscription, GeneticJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReview

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Young-Jun Park, Karolin Luger. 2006. Structure and function of nucleosome assembly proteins.. https://doi.org/10.1139/o06-088

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