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PubMed · 16942869

Solution NMR in structural genomics.

Adelinda Yee·Aleksandras Gutmanas·Cheryl H Arrowsmith
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Abstract

Structural genomics (also known as structural proteomics) aims to generate accurate three-dimensional models for all folded, globular proteins and domains in the protein universe to understand the relationship between protein sequence, structure and function. NMR spectroscopy of small (<20 kDa) proteins has been used successfully within several large-scale structural genomics projects for more than six years now. Recent advances coming from traditional NMR structural biology laboratories as well as large scale centers and consortia using NMR for structural genomics promise to facilitate NMR analysis making it even a more efficient and increasingly automated procedure.

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AnimalsGenomicsHumansMagnetic Resonance SpectroscopyProteinsSolutionsJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReview

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Adelinda Yee, Aleksandras Gutmanas, Cheryl H Arrowsmith. 2006-08-30. Solution NMR in structural genomics.. https://doi.org/10.1016/j.sbi.2006.08.002

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