RNA-interference effectors and their delivery.

D Putnam; A Doody

doi:10.1615/critrevtherdrugcarriersyst.v23.i2.30

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PubMed · 16952275

RNA-interference effectors and their delivery.

D Putnam·A Doody

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Abstract

RNA-interference, the mechanism by which the expression of a specific protein can be reduced or eliminated, has emerged as a potential way to treat disease. RNA-interference effectors, such as small interfering RNA and small hairpin RNA, are double-stranded nucleic acid sequences expressly designed to have homology to sections of the target protein's mRNA, and when present in the cytosol trigger hydrolysis of the mRNA through the RNA-interference pathway. Because RNA-interference effectors are macromolecular and typically polyanionic, their efficacy is poor when not accompanied by a delivery vehicle. This review outlines the RNA-interference mechanism and discusses the delivery of RNA-interference effectors, with an emphasis on synthetic polymer-based delivery systems.

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Animals Breast Neoplasms Cyclodextrins Drug Delivery Systems Electroporation Female Genetic Vectors Humans Polyethyleneimine Protamines RNA Interference RNA Stability RNA, Small Interfering Journal Article Review

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D Putnam, A Doody. 2006. RNA-interference effectors and their delivery.. https://doi.org/10.1615/critrevtherdrugcarriersyst.v23.i2.30

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