Walking through protein sequence space.

Zakharia M Frenkel; Edward N Trifonov

doi:10.1016/j.jtbi.2006.07.027

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Walking through protein sequence space.

Zakharia M Frenkel·Edward N Trifonov

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Abstract

Following the original idea of Maynard Smith on evolution of the protein sequence space, a novel tool is developed that allows the "space walk", from one sequence to its likely evolutionary relative and further on. At a given threshold of identity between consecutive steps, the walks of many steps are possible. The sequences at the ends of the walks may substantially differ from one another. In a sequence space of randomized (shuffled) sequences the walks are very short. The approach opens new perspectives for protein evolutionary studies and sequence annotation.

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ATP-Binding Cassette Transporters Amino Acid Sequence Evolution, Molecular Molecular Sequence Data Proteins Sequence Analysis, Protein Journal Article Research Support, Non-U.S. Gov't

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Zakharia M Frenkel, Edward N Trifonov. 2006-07-28. Walking through protein sequence space.. https://doi.org/10.1016/j.jtbi.2006.07.027

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